- John Wall, Martyr and Saint (1620–1679)
- Richard Arkwright (1732–1792) — inventor of the water frame that kick-started the textile industry in the late 18th century
- Joseph Livesey (1794–1884) — Social reformer and pioneer of the Temperance movement in the 19th century
- Edith Rigby (1872 – 1948) — Suffragette
- Kenny Baker (b. 1934)— an actor who plays R2D2 in Star Wars.
- AJP Taylor (1906–1990) — historian.
- Sir Tom Finney (b. 1922) — Footballer
- Andrew Flintoff (b. 1977) — Cricketer
- Ian McCulloch (b. 1971) — snooker player currently in the top 16 of the world rankings
- Mark Lawrenson (b. 1957 –) — Footballer turned football pundit
- Nick Park (b. 1958) — animator famous mainly for the Wallace and Gromit and Chicken Run claymation animation classics.
- Jason Queally (b. 1970) — Cyclist who won a gold and a silver medal at the 2000 Summer Olympics in Sydney.
- John Inman-Comedy actor and drag artiste:
- Roy Barraclough-Actor from Coronation Street
- Francis Thompson (1859–1907) — poet
- Eddie Calvert (Trumpeter "The Man With The Golden Horn")
- Butch Cassidy (Wild West Outlaw)
- Professor Sir George Grenfell Baines, OBE (1908 – 2003, — Architect, pioneer of multi-disciplinary design and founder of the Building Design Partnership
- Gregory Doran (b. 1958) — Associate Director, Royal Shakespeare Company.
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